Gerard Deulofeu and Paco Alcacer have been given the nod to partner Lionel Messi in a threadbare Barcelona attack for their La Liga opener against Real Betis.
Barca boss Ernesto Valverde has seen his forward line decimated of late following the loss of Neymar to Paris Saint-Germain and Luis Suarez's month-long layoff with a knee injury.
Valverde can still call upon star man Messi, who will start alongside returning academy product Deulofeu and ex-Valencia attacker Alcacer.
The backline has also been broken up somewhat, as Gerard Pique is only fit enough for a place on the bench due to a minor muscle injury, while Andres Iniesta misses out completely.
Nelson Semedo is handed a league debut at right-back, but fellow new recruit Paulinho is made to wait for his La Liga bow after joining from Guangzhou Evergrande earlier this week.
The visitors, without a win against Barcelona in 12 attempts, have a number of new arrivals in their squad, though ex-Barcelona ace Cristian Tello is absent through injury.
Victor Camarasa, Sergio Leon, Zouhair Feddal, Andres Guardado, Juan Jose Narvaez and Antonio Barragan all come in from the off for the Verderones, who are aiming to better last season's 12th-place finish in the Spanish top flight.
Barcelona: Ter Stegen; Semedo, Mascherano, Umtiti, Alba; Busquets, Rakitic, Roberto; Messi, Deulofeu, Alcacer
Subs: Cillessen, Pique, Denis Suarez, Turan, Digne, Andre Gomes, Aleix Vidal
Real Betis: Adan; Barragan, Mandi, Feddal, Tosca; Guardado, Camarasa, Narvaez, Joaquin, Nahue; Sergio Leon
Subs: Gimenez, Jordi Amat, Durmisi, Javi Garcia, Fabian, Sanabria
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